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CNS recurrence following CD34^+^ peripheral blood stem cell transplantation in stage 4 neuroblastoma by Hyoung Soo Choi; Sang Hyeok Koh; Eun Sil Park; Hee Young Shin; Hyo Seop Ahn is a Medicine article available to read on EtoBox.

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## Abstract We report here central nervous system (CNS) recurrence in neuroblastoma (NBL) after CD34^+^ peripheral blood stem cell transplantation (PBSCT). Fifteen stage 4 NBL patients underwent CD34^+^ transplantation with myeloablative chemotherapy consisting of carboplatin, etoposide, and melphalan. There were three primary site recurrences and five distant metastases including four brain metastases (two isolated CNS recurrences) at 4–7 months after CD34^+^ transplantation. Three of four patients died of CNS progressive disease at 2, 8, and 9 months after recurrence and the remaining single patient was lost to follow‐up. CNS recurrence in NBL is fatal and requires identification of risk factors and more effective treatment strategies. Pediatr Blood Cancer 2005; 45:68–71. © 2005 Wiley‐Liss, Inc.

Who reads CNS recurrence following CD34^+^ peripheral blood stem cell transplantation in stage 4 neuroblastoma?

Author

Hyoung Soo Choi; Sang Hyeok Koh; Eun Sil Park; Hee Young Shin; Hyo Seop Ahn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2005

Language

EN

Field

Medicine (Health Sciences)