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Radical Scavenging Properties of Polyamines by G. Drolet; E.B. Dumbroff; R.L. Legge; J.E. Thompson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Key Word Iadex-Polyamincs; free radicals; lipid peroxidation; senescence. Abstnct-Diand polyamines are effective scavengers of free radicals generated in a number of chemical and in vitro enzyme systems. Free radical production was qua&&d s~trophotomet~~y using ~itroblue tetrazolium and ~t~hrome c or by electron spin resonance. Levels of superoxide radical formed either enzymatically with xanthine oxidase or chemi~~y from ribofIavin or pyrogallol were sig~~ntIy inhibited by spermine, spermidine, putrescine and cadaverine at 10 and 50 mM. The more reactive hydroxyl radical generated by the Fenton reaction was also effectively scavenged by di-and polyamines. In addition, the production of superoxide radical by senescing microsomal membranes was inhibited by di-and polyamines, as was the superoxide-dependent conversion of l-~n~ciopro~~l~r~xylic acid (ACC) to ethylene. The efficacy of ~lya~ne-evening appears to be correlated with the extent of amination su~~~g the involvement of amino groups. It is also apparent that some of the physiolo~~l effects of polyamines, in particular their propensity to inhibit lipid ~roxi~tion and retard senescence, may be attributable to their radical-scave

Who reads Radical Scavenging Properties of Polyamines?

Author

G. Drolet; E.B. Dumbroff; R.L. Legge; J.E. Thompson

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0031-9422)

Published

1986

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)