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The study identifies a novel human protein, hCRELD2b, that specifically interacts with the large cytoplasmic regions of the human nicotinic acetylcholine receptor subunits a4 and b2, but not with a7 and a3 subunits. CRELD2 is localized in the endoplasmic reticulum and is suggested to regulate the expression and membrane transport of a4b2 nAChRs. The research highlights the importance of CRELD2 in the assembly and modulation of nAChRs, which are critical for synaptic signaling in the central and peripheral n

Author

beltracastillomartin

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EN