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Can I read Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU) 2 Zn(CF 2 H) 2 ] and Improved Synthesis of the ICHF 2 Precursor on EtoBox?
Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU) 2 Zn(CF 2 H) 2 ] and Improved Synthesis of the ICHF 2 Precursor by Monfette, Sebastien; Fang, Yuan-Qing; Bio, Matthew M.; Brown, Adam R.; Crouch, Ian T.; Desrosiers, Jean-Nicolas; Duan, Shengquan; Hawkins, Joel M.; Hayward, Cheryl M.; Peperni, Nikita; Rainville, Joseph P. is a Chemistry article available to read on EtoBox.
What is Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU) 2 Zn(CF 2 H) 2 ] and Improved Synthesis of the ICHF 2 Precursor about?
Complex [(DMPU) 2 Zn(CF 2 H) 2 ] 1 is a crystalline organometallic reagent with utility in various catalytic difluoromethylation reactions under mild conditions. Unfortunately, this reagent is not commercially available and the procedure for the preparation of this air-and moisture-sensitive zinc complex has only been reported on a small scale. Herein, we report the development of a continuous process for the preparation of reagent 1 on >100 g scale by using a continuous stirred-tank reactor. The key to success is the design of a continuous reactive crystallization process in which the precipitation of the zinc complex 1 is driven by its low solubility in the reaction solvent. The improved synthesis of the iododifluoromethane precursor 2 from readily available bromodifluoroacetic acid further enables the synthesis of complex 1 on a larger scale.
Who reads Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU) 2 Zn(CF 2 H) 2 ] and Improved Synthesis of the ICHF 2 Precursor?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Monfette, Sebastien; Fang, Yuan-Qing; Bio, Matthew M.; Brown, Adam R.; Crouch, Ian T.; Desrosiers, Jean-Nicolas; Duan, Shengquan; Hawkins, Joel M.; Hayward, Cheryl M.; Peperni, Nikita; Rainville, Joseph P.
- Publisher
- American Chemical Society; American Chemical Society (ACS) (ISSN 1083-6160)
- Published
- 2020
- Language
- EN
- Field
- Chemistry (Physical Sciences)