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Metabolic Pattern of Systemic Sclerosis: Association of Changes in Plasma Concentrations of Amino Acid-Related Compounds With Disease Presentation by Smolenska, Zaneta; Zabielska-Kaczorowska, Magdalena; Wojteczek, Anna; Kutryb-Zajac, Barbara; Zdrojewski, Zbigniew is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Objective: Amino acids (aa) and their derivatives play an integral role in the synthesis of structural and regulatory elements in human organisms and therefore pathologies such as systemic sclerosis that may alter the blood pattern of these compounds. this study aimed to evaluate changes in plasma concentrations of amino acid-related metabolites in systemic sclerosis in a search for potential biomarkers and mechanisms of the disease. ## Methods: Plasma samples from 42 patients diagnosed with systemic sclerosis (ssc) according to the 2013 american college of rheumatology and european league against rheumatism acr/eular classification criteria were compared to 27 matched healthy controls. liquid chromatography/mass spectrometry was applied for the analysis of 36 amino acid-related metabolites. ## Results: The analysis of plasma aa metabolite patterns revealed the number of changes including an increase (20%) in concentrations of no synthase (nos) inhibitor asymmetric dimethylarginine (adma) in ssc vs. healthy subjects. furthermore, ssc patients had higher glutamine, proline, betaine, 1-methylhistidine, and methylnicotinamide levels, while the concentration of tryptophan was lower.

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Author

Smolenska, Zaneta; Zabielska-Kaczorowska, Magdalena; Wojteczek, Anna; Kutryb-Zajac, Barbara; Zdrojewski, Zbigniew

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2014- (ISSN 2296-889X)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)