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Dosing strategies for switching from oral risperidone to paliperidone palmitate: Effects on clinical outcomes by Stephanie L. Hsia; Susan G. Leckband; Sanjai Rao; Elizabeth Jackson; Jonathan P. Lacro is a Medicine article available to read on EtoBox.

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## Introduction: There are currently no guidelines for switching patients from oral risperidone to paliperidone palmitate (Invega Sustenna®). Furthermore, the paliperidone long-acting injectable (LAI) package insert does not recommend bridging with oral antipsychotics, which may result in inadequate serum concentrations in patients on ≥4 mg/d risperidone. ## Methods: This study evaluated the effects of suboptimal dosing and bridging in patients switched from oral risperidone to paliperidone LAI on hospitalization days, emergency department (ED)/mental health urgent care visits, and no-shows/cancellations to mental health appointments. Patients were categorized into __optimal__ or __suboptimal__ dosing based on their loading and maintenance paliperidone doses. Patients on risperidone ≥4 mg/d were categorized as __bridged__ if they received risperidone for ≥7 days after the first paliperidone injection. ## Results: There were no significant differences in outcomes between optimally and suboptimally dosed patients. There were statistically significant reductions in hospitalization days in patients who were bridged compared with patients who were not bridged. There were statistically s

Who reads Dosing strategies for switching from oral risperidone to paliperidone palmitate: Effects on clinical outcomes?

Author

Stephanie L. Hsia; Susan G. Leckband; Sanjai Rao; Elizabeth Jackson; Jonathan P. Lacro

Publisher

College of Psychiatric and Neurologic Pharmacists (CPNP)

Published

2018

Language

EN

Field

Medicine (Health Sciences)