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Calcipotriene-induced Improvement in Psoriasis Is Associated with Reduced Interleukin-8 and Increased Interleukin-10 Levels Within Lesions by S Kang; S Yi; C E Griffiths; L Fancher; T A Hamilton; J H Choi is a Medicine article available to read on EtoBox.
What is Calcipotriene-induced Improvement in Psoriasis Is Associated with Reduced Interleukin-8 and Increased Interleukin-10 Levels Within Lesions about?
Calcipotriene is a synthetic analogue of 1,25-dihydroxyvitamin D3 established to be effective topically in the treatment of psoriasis. We investigated the early cellular and immunological events induced by calcipotriene in psoriasis. Thirty patients with moderate plaque-type psoriasis were randomly assigned to receive twice daily applications of either calcipotriene ointment 0.005% or matching vehicle for 6 weeks. Skin biopsies (6 mm) were performed from designated plaques at baseline and days 3 and 7. On these days and at weeks 2, 4 and 6, complete clinical evaluations were made in a double-blind fashion. Consistent with previous studies, significant clinical improvement (P < 0.05) in psoriasis was observed in patients receiving calcipotriene vs. those receiving vehicle by day 7 for scale and erythema, and by day 14 for thickness. No significant improvement, however, was seen on day 3. None of the immunohistological markers (CD1a, CD4, CD8, ICAM-1, VCAM-1, E-selectin, HLA-DR) semiquantitatively assessed in psoriatic plaques was significantly changed by calcipotriene treatment for 7 days. In the calcipotriene-treated group, interleukin (IL)-10 levels (pg/microgram of protein) incre
Who reads Calcipotriene-induced Improvement in Psoriasis Is Associated with Reduced Interleukin-8 and Increased Interleukin-10 Levels Within Lesions?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- S Kang; S Yi; C E Griffiths; L Fancher; T A Hamilton; J H Choi
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Springer Science and Business Media LLC (ISSN 0007-0963)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)