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Rare Immune-Related Adverse Events (irAEs): Approach to Diagnosis and Management by Anadil Javaid; Catherine Bennett; Aparna Rao; Lavinia Spain is a Medicine article available to read on EtoBox.

What is Rare Immune-Related Adverse Events (irAEs): Approach to Diagnosis and Management about?

Immune checkpoint inhibitors (ICIs) have revolutionised the treatment landscape across many solid organ malignancies and form part of routine clinical practice in many tumours. As indications for monotherapy, doublet therapy and combination approaches with chemotherapy and targeted agents expand, clinicians must be aware of the wide range of possible immune-related adverse events (irAEs). Common toxicities, including rash, colitis, hepatitis and pneumonitis are well described in the literature, and have established diagnostic and management algorithms. Rarer toxicities, often with an incidence of less than 1%, are less defined. These syndromes can be poorly recognised, may take on a fulminant course and do not have established or evidence-based diagnostic and management strategies. As such, patients may experience increased morbidity, mortality and poorer outcomes, related both to these irAEs as well as how the treatment of these may affect the management of their underlying malignancy. In this review, we aim to explore the incidence, potential biomarkers, pathogenesis, diagnostic work-up and clinical sequelae of a selection of uncommon irAEs, with a focus on myocarditis, neurologi

Who reads Rare Immune-Related Adverse Events (irAEs): Approach to Diagnosis and Management?

Author

Anadil Javaid; Catherine Bennett; Aparna Rao; Lavinia Spain

Publisher

Springer

Published

2024

Language

EN

Field

Medicine (Health Sciences)