Opening book details…
Can I read Chronic Exposure to Environmentally Relevant Levels of Simvastatin Disrupts Zebrafish Brain Gene Signaling Involved in Energy Metabolism on EtoBox?
Chronic Exposure to Environmentally Relevant Levels of Simvastatin Disrupts Zebrafish Brain Gene Signaling Involved in Energy Metabolism by Barros, Susana; Coimbra, Ana M.; Alves, Nélson; Pinheiro, Marlene; Quintana, José Benito; Santos, Miguel M.; Neuparth, Teresa is a Environmental Science article available to read on EtoBox.
What is Chronic Exposure to Environmentally Relevant Levels of Simvastatin Disrupts Zebrafish Brain Gene Signaling Involved in Energy Metabolism about?
Simvastatin (SIM), a hypocholesterolaemic drug belonging to the statins group, is a widely prescribed pharmaceutical for prevention of cardiovascular diseases. Several studies showed that lipophilic statins, as SIM, cross the blood-brain barrier and interfere with the energy metabolism of the central nervous system in humans and mammalian models. In fish and other aquatic organisms, the effects of SIM on the brain energy metabolism are unknown, particularly following exposure to low environmentally relevant concentrations. Therefore, the present study aimed at investigating the influence of SIM on gene signaling pathways involved in brain energy metabolism of adult zebrafish () following chronic exposure (90 days) to environmentally relevant SIM concentrations ranging from 8 ng/L to 1000 ng/L. Real-time PCR was used to determine the transcript levels of several genes involved in different pathways of the brain energy metabolism (, and ). The findings here reported integrated well with ecological and biochemical responses obtained in a parallel study. Data demonstrated that SIM modulates transcription of key genes involved in the mitochondrial electron transport chain, in glucose tr
Who reads Chronic Exposure to Environmentally Relevant Levels of Simvastatin Disrupts Zebrafish Brain Gene Signaling Involved in Energy Metabolism?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Barros, Susana; Coimbra, Ana M.; Alves, Nélson; Pinheiro, Marlene; Quintana, José Benito; Santos, Miguel M.; Neuparth, Teresa
- Publisher
- Taylor and Francis Group; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 1087-2620)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Physical Sciences)