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New X-linked syndrome of mental retardation, gynecomastia, and obesity is linked to DXS255 by Meredith Wilson; John Mulley; Agi Gedeon; Hazel Robinson; Gillian Turner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is New X-linked syndrome of mental retardation, gynecomastia, and obesity is linked to DXS255 about?
We describe 14 males from 3 successive generations in a family who have X-linked mental retardation (XLMR), obesity, gynecomastia, speech difficulties, emotional lability, tapering fingers, and small feet. Linkage analysis using markers spread along the X chromosome demonstrated a gene localisation close to the centromere. Maximum lod scores for markers near the centromere, all at 8 = 0.00, were 1.36 for DXS7, 4.82 for DXS255, 2.79 for DXS14, 2.09 for DXS72, and 1.46 for DXYSl. The closest flanking markers which showed recombination were DXSM and DXS94, defining the physical localisation within Xp21.1-q22. DXS255 was fully informative with lod-1 confidence interval for 8 of 0.00-0.12. Clinical findings and linkage data in this family distinguish it from the Borjeson-Forssman-Lehmann syndrome and other previously described XLMR syndromes.
Who reads New X-linked syndrome of mental retardation, gynecomastia, and obesity is linked to DXS255?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Meredith Wilson; John Mulley; Agi Gedeon; Hazel Robinson; Gillian Turner
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)
- Published
- 1991
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)