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Can I read The Mutant Eisai Hyperbilirubinemic Rat Is Resistant to Bile Acid–induced Cholestasis and Cytotoxicity on EtoBox?
The Mutant Eisai Hyperbilirubinemic Rat Is Resistant to Bile Acid–induced Cholestasis and Cytotoxicity by Makoto Hoshino; Tomihiro Hayakawa; Asamitsu Hirano; Yasutaka Kamiya; Takayuki Ohiwa; Akitaka Tanaka; Tomoyuki Kumai; Takanori Inagaki; Makoto Miyaji; Toshihiko Takeuchi is a Medicine article available to read on EtoBox.
What is The Mutant Eisai Hyperbilirubinemic Rat Is Resistant to Bile Acid–induced Cholestasis and Cytotoxicity about?
We investigated bile flow and biliary excretion of bile acids in the Eisai hyperbilirubinemic rat, a Sprague-Dawley mutant rat with conjugated hyperbilirubinemia, using both in uiuo and in uitro models. In uiuo bile flow was lower in Eisai hyperbilirubinemic rats than in the control rats before and after taurocholate was infused. After taurocholate was infused, bile acid output was similar in the Eisai hyperbilirubinemic rats and control rats. In the isolated perfused rat liver, biliary excretion of bile acids was higher in the Eisai hyperbilirubinemic rats than in the control rats after a high-dose infusion of taurocholate (0.33 pmol/min/gm liver). Infusion of taurochenodeoxycholate (0.22 pmol/min/gm liver) did not produce cholestasis and did not reduce the biliary excretion of bile acids in the Eisai hyperbilirubinemic rats. Taurochenodeoxycholate significantly increased the phospholipidbile acid molar ratio and slightly reduced bile acid-induced alkaline phosphatase output into bile. The release of lactate dehydrogenase from the perfused liver 30 min after the start of the taurochenodeoxycholate infusion was 10 times lower in the Eisai hyperbilirubinemic rats than in the control
Who reads The Mutant Eisai Hyperbilirubinemic Rat Is Resistant to Bile Acid–induced Cholestasis and Cytotoxicity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Makoto Hoshino; Tomihiro Hayakawa; Asamitsu Hirano; Yasutaka Kamiya; Takayuki Ohiwa; Akitaka Tanaka; Tomoyuki Kumai; Takanori Inagaki; Makoto Miyaji; Toshihiko Takeuchi
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 1994
- Language
- EN
- Field
- Medicine (Health Sciences)