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What is Selective Inhibitors of Lysosomal α-Glucosidase about?

This study presents a design strategy for selective inhibitors of lysosomal acid α-glucosidase (GAA), focusing on the alkyl chain storage site to improve selectivity over other α-glucosidases. The synthesized compound α-1-C-heptyl-1,4-dideoxy-1,4-imino-l-arabinitol (LAB) demonstrated a potent inhibitory effect on GAA with an IC50 of 0.44 µM and a selectivity index of 168.2. The findings suggest that tailoring the alkyl chain length can enhance binding interactions and selectivity for GAA, which may lead to

Author

kastistorm

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EN