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The Intrathecal Humoral Immune Response: Laboratory Analysis and Clinical Relevance by Christian J.M. Sindic; Marie-Paule Van Antwerpen; Sophie Goffette is a Medicine article available to read on EtoBox.

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In normal conditions, albumin and immunoglobulin (Ig)G in the cerebrospinal fluid (CSF) originate from the blood, and there is no antibody production within the central nervous system. Up to 20% of CSF proteins are intrathecally synthesized, but the major fraction is blood-derived. The CSF/serum albumin quotient (Q Alb ) is the best marker of the blood-CSF barrier function. The corresponding immunoglobulin quotients (Q IGG , Q IGA, Q IGM ) are not linearly related to Q Alb and their correlations are defined by an hyperbolic equation. This equation is used to discriminate between a blood-derived and a locally produced fraction of immunoglobulins in case of an intrathecal humoral immune response. The detection of CSF-specific oligoclonal IgG is more sensitive than the quantitative comparison between Q IGG and Q A l b . A further step is the determination of antibody indices and the detection of specific oligoclonal antibodies by antigen-driven immunoblots. CSF analysis remains a cornerstone for the diagnosis of various neurological disorders, including multiple sclerosis and infectious diseases of the central nervous system.

Who reads The Intrathecal Humoral Immune Response: Laboratory Analysis and Clinical Relevance?

Author

Christian J.M. Sindic; Marie-Paule Van Antwerpen; Sophie Goffette

Publisher

Walter de Gruyter GmbH

Published

2001

Language

EN

Field

Medicine (Health Sciences)