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Associations of lipoprotein subclasses with risk of all‐cause and cardiovascular disease mortality in individuals with type 2 diabetes: A prospective cohort study by Rui Li; Jun‐Xiang Chen; Qi Lu; Ting‐Ting Geng; Peng‐Fei Xia; Yi Wang; Liang‐Kai Chen; Zhi‐Lei Shan; An Pan; Gang Liu is a Medicine article available to read on EtoBox.
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## Abstract ## Aim Although lipoproteins are well‐established risk factors for cardiovascular disease (CVD) mortality, conventional measurements failed to identify lipoprotein particle sizes. This study aimed to investigate associations of lipoprotein subclasses categorized by particle sizes with risk of all‐cause and CVD mortality in individuals with type 2 diabetes. ## Methods This study included 6575 individuals with type 2 diabetes from the UK Biobank. Concentrations of very low‐, low‐, intermediate‐ and high‐density lipoprotein [very‐low‐density lipoprotein (VLDL), low‐density lipoprotein (LDL), intermediate‐density lipoprotein and high‐density lipoprotein (HDL)] particles in 14 subclasses and lipid constituents within each subclass were measured by quantitative nuclear magnetic resonance. Multivariable‐adjusted Cox proportional‐hazard regression models were used to estimate the hazard ratio (HR) for per standard deviation increment of log‐transformed lipoprotein subclasses with risk of mortality. All p‐values were adjusted by the false discovery rate method. ## Results During a median follow‐up of 11.4 years, 943 deaths were documented, including 310 CVD deaths. Small HDL par
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- Author
- Rui Li; Jun‐Xiang Chen; Qi Lu; Ting‐Ting Geng; Peng‐Fei Xia; Yi Wang; Liang‐Kai Chen; Zhi‐Lei Shan; An Pan; Gang Liu
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)