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Can I read Transcuprein Is a Macroglobulin Regulated by Copper and Iron Availability on EtoBox?
Transcuprein Is a Macroglobulin Regulated by Copper and Iron Availability by Nanmei Liu; Louis Shi-li Lo; S. Hassan Askary; LaTrice Jones; Theodros Z. Kidane; Trisha Trang Minh Nguyen; Jeremy Goforth; Yu-Hsiang Chu; Esther Vivas; Monta Tsai; Terence Westbrook; Maria C. Linder is a Medicine article available to read on EtoBox.
What is Transcuprein Is a Macroglobulin Regulated by Copper and Iron Availability about?
Transcuprein is a high-affinity copper carrier in the plasma that is involved in the initial distribution of copper entering the blood from the digestive tract. To identify and obtain cDNA for this protein, it was purified from rat plasma by size exclusion and copper-chelate affinity chromatography, and amino acid sequences were obtained. These revealed a 190-kDa glycosylated protein identified as the macroglobulin a 1 -inhibitor III, the main macroglobulin of rodent blood plasma. Albumin (65 kDa) copurified in variable amounts and was concluded to be a contaminant (although it can transiently bind the macroglobulin). The main macroglobulin in human blood plasma (a 2 -macroglobulin), which is homologous to a 1 -inhibitor III, also bound copper tightly. Expression of a 1 I3 (transcuprein) mRNA by the liver was examined in rats with and without copper deficiency, using quantitative polymerase chain reaction methodology and Northern blot analysis. Protein expression was examined by Western blotting. Deficient rats with 40% less ceruloplasmin oxidase activity and liver copper concentrations expressed about twice as much a 1 I3 mRNA, but circulating levels of transcuprein did not differ
Who reads Transcuprein Is a Macroglobulin Regulated by Copper and Iron Availability?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nanmei Liu; Louis Shi-li Lo; S. Hassan Askary; LaTrice Jones; Theodros Z. Kidane; Trisha Trang Minh Nguyen; Jeremy Goforth; Yu-Hsiang Chu; Esther Vivas; Monta Tsai; Terence Westbrook; Maria C. Linder
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0955-2863)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)