Opening book details…
Can I read Effects of Ions and Detergents in Drug Partition Chromatography on Liposomes on EtoBox?
Effects of Ions and Detergents in Drug Partition Chromatography on Liposomes by Elisabet Boija; Anna Lundquist; Juan José Martı́nez Pla; Caroline Engvall; Per Lundahl is a Chemistry article available to read on EtoBox.
What is Effects of Ions and Detergents in Drug Partition Chromatography on Liposomes about?
We have determined drug partitioning into phospholipid bilayers by immobilized-liposome chromatography (ILC). Electrostatic effects on the drug partitioning were observed on neutral bilayers at low ionic strength. The size of the counterions affected the partitioning. When liposomes were supplemented with ionic detergents the partitioning of charged drugs was strongly affected, allowing complete separation of drugs of different charges which showed similar retention on neutral bilayers. Partial separation was obtained on bilayers containing fatty acid. Detergent ions or fatty acid inserted into phospholipid bilayers affected the partitioning of drugs much more than did free ions or phospholipid head group charges.
Who reads Effects of Ions and Detergents in Drug Partition Chromatography on Liposomes?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Elisabet Boija; Anna Lundquist; Juan José Martı́nez Pla; Caroline Engvall; Per Lundahl
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 2004
- Language
- EN
- Field
- Chemistry (Physical Sciences)