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Histopathological findings after treatment of prostate cancer using high‐intensity focused ultrasound (HIFU) by Katharina Biermann; Rodolfo Montironi; Antonio Lopez‐Beltran; Shaobo Zhang; Liang Cheng is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND High‐intensity focused ultrasound (HIFU) treatment is a novel minimally invasive therapeutic option for patients with localized prostate cancer. Little is known about the histological findings in prostate biopsies upon HIFU treatment. ## METHOD We examined the spectrum of histological changes in prostate biopsies of 25 prostate cancer patients who were previously treated with HIFU. The biopsies were taken 180 days after HIFU treatment. ## RESULTS Seventy‐two percent of the cases showed necrosis, often accompanied by acute, chronic, or granulomatous inflammation. Mild or moderate fibrosis was present in all biopsies. In benign glands, histological examination revealed a heterogeneous cellular damage and cellular response including cytologic atypia and basal cell hyperplasia. Eleven patients (44%) had residual prostatic carcinoma after treatment. In cases with residual adenocarcinoma, the majority of the cases (9/11, 88%) do no have apparent treatment effects. Two cases showed nuclear pyknosis. In summary, we report the histological findings in benign and malignant prostatic tissues after HIFU treatment. These findings include a spectrum of morphological cha

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Author

Katharina Biermann; Rodolfo Montironi; Antonio Lopez‐Beltran; Shaobo Zhang; Liang Cheng

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2010

Language

EN

Field

Medicine (Health Sciences)