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Effects of a 1% Hydrocortisone Conditioner on Haematological and Biochemical Parameters, Adrenal Function Testing and Cutaneous Reactivity to Histamine in Normal and Pruritic Dogs by Thomas; Logas; Radosta; Harrison is a Medicine article available to read on EtoBox.

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The purpose of this double‐blinded study was to examine the effects of a 1% hydrocortisone, leave‐on conditioner on haematological and biochemical parameters, adrenal function tests, and cutaneous reaction to serial dilutions of histamine phosphate in normal dogs and those with pruritic dermatitis. Groups 1 and 2 each consisted of eight normal dogs. Seven pruritic dogs comprised Group 3. All dogs were bathed twice weekly for 6 weeks. Groups 1 and 3 had 1% hydrocortisone conditioner applied after each bath. Group 2 had vehicle from the conditioner applied after each bath. The amount of 1% hydrocortisone applied to the treated dogs ranged from 278 to 416 mg/m^2^. Haematological and biochemical analysis and adrenocorticotrophic hormone (ACTH) stimulation tests were performed on all dogs on days 0, 14, 28, and 42. Mean values for all blood and serum parameters remained within normal limits during the study. Post‐ACTH cortisol levels were significantly lower in Group 3 compared to Groups 1 and 2 on day 42 (__P__ < 0.05) and when averaged over all days of the study (__P__ < 0.05 and __P__ < 0.01, respectively). Serum alkaline phosphatase levels were significantly lower in Group 3 on day

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Author

Thomas; Logas; Radosta; Harrison

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0959-4493)

Published

1999

Language

EN

Field

Medicine (Health Sciences)