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Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae by Philip W. Lowry; Amy L. Weaver; William J. Tremaine; Dr. William J. Sandborn is a Medicine article available to read on EtoBox.

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Our aim was to report the clinical experience with combination treatment using tacrolimus and either azathioprine (AZA) or 6-mercaptopurine (6MP) in patients with Crohn's disease (CD) perianal fistulae. The medical records of all patients with Crohn's disease perianal fistulae seen at the Mayo Clinic from 1996-1998 who were treated with tacrolimus were reviewed. Clinical response was classified as: complete response, partial response, and nonresponse. Eleven patients were treated with oral tacrolimus for a mean duration of 22 weeks. The initial oral dose of tacrolimus ranged from 0.15 to 0.31 mg/kg/day. Azathioprine or 6MP was continued in combination with tacrolimus in seven patients and initiated simultaneously with tacrolimus in four patients. All patients improved clinically, seven had a complete response, and four had a partial response. The mean time to initial improvement was 2.4 weeks, and the mean time to complete response was 12.2 weeks. The most frequent adverse events were nausea, paresthesias, nephrotoxicity, and tremor. Patients with nephrotoxicity had a significantly higher mean initial tacrolimus dose (0.3 1 mg/kg/day) compared with patients who did not have nephrot

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Author

Philip W. Lowry; Amy L. Weaver; William J. Tremaine; Dr. William J. Sandborn

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP) (ISSN 1078-0998)

Published

2007

Language

EN

Field

Medicine (Health Sciences)