Opening book details…
Can I read Effect of probiotics on gut microbiome in patients with administration of surgical antibiotic prophylaxis: A randomized controlled study on EtoBox?
Effect of probiotics on gut microbiome in patients with administration of surgical antibiotic prophylaxis: A randomized controlled study by Norihito Kaku; Nariyoshi Matsumoto; Daisuke Sasaki; Keiichi Tsuda; Kosuke Kosai; Naoki Uno; Yoshitomo Morinaga; Atsushi Tagami; Shinji Adachi; Hiroo Hasegawa; Makoto Osaki; Katsunori Yanagihara is a Medicine article available to read on EtoBox.
What is Effect of probiotics on gut microbiome in patients with administration of surgical antibiotic prophylaxis: A randomized controlled study about?
Surgical antibiotic prophylaxis (SAP) is recommended for the prevention of surgical site infections. However, there is a concern about adverse effects of SAP, such as antibiotic-associated diarrhea (AAD). To prevent AAD, administration of probiotics has been investigated. Although recent advances in next-generation sequencing makes it possible to analyze the gut microbiome, the effect of probiotics on the gut microbiome in the patients with SAP remains unknown. To test a hypothesis that SAP influences the gut microbiome and probiotics prevent the influence, a randomized controlled study was conducted with patients who underwent spinal surgery at Nagasaki University Hospital. After obtaining informed consent, the patients were automatically classified into the non-probiotics group and the probiotics group. In the probiotics group, the patients took 1 g of Enterococcus faecium 129 BIO 3B-R, 3 times a day on postoperative days (PODs) 1-5. The feces of all patients were sampled before administration of SAP and on PODs 5 and 10. We compared alpha and beta diversity and differential abundance analysis of the gut microbiome before and after SAP. During the study period, a total of 33 pati
Who reads Effect of probiotics on gut microbiome in patients with administration of surgical antibiotic prophylaxis: A randomized controlled study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Norihito Kaku; Nariyoshi Matsumoto; Daisuke Sasaki; Keiichi Tsuda; Kosuke Kosai; Naoki Uno; Yoshitomo Morinaga; Atsushi Tagami; Shinji Adachi; Hiroo Hasegawa; Makoto Osaki; Katsunori Yanagihara
- Publisher
- Springer; Elsevier ; Elsevier Limited; Elsevier BV (ISSN 1341-321X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)