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Can I read An Ancestral Mycobacterial Effector Promotes Dissemination of Infection on EtoBox?
An Ancestral Mycobacterial Effector Promotes Dissemination of Infection by Joseph W. Saelens; Mollie I. Sweeney; Gopinath Viswanathan; Ana María Xet-Mull; Kristen L. Jurcic Smith; Dana M. Sisk; Daniel D. Hu; Rachel M. Cronin; Erika J. Hughes; W. Jared Brewer; Jörn Coers; Matthew M. Champion; Patricia A. Champion; Craig B. Lowe; Clare M. Smith; Sunhee Lee; Jason E. Stout; David M. Tobin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is An Ancestral Mycobacterial Effector Promotes Dissemination of Infection about?
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting with unusually high rates of extrapulmonary dissemination and bone disease. We found that the causal strain carried an ancestral full-length version of the type VII-secreted effector EsxM rather than the truncated version present in other modern Mtb lineages. The ancestral EsxM variant exacerbated dissemination through enhancement of macrophage motility, increased egress of macrophages from established granulomas, and alterations in macrophage actin dynamics. Reconstitution of the ancestral version of EsxM in an attenuated modern strain of Mtb altered the migratory mode of infected macrophages, enhancing their motility. In a zebrafish model, full-length EsxM promoted bone disease. The presence of a derived nonsense variant in EsxM throughout the major Mtb lineages 2, 3, and 4 is consistent with a role for EsxM in regulating the extent of dissemination.
Who reads An Ancestral Mycobacterial Effector Promotes Dissemination of Infection?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Joseph W. Saelens; Mollie I. Sweeney; Gopinath Viswanathan; Ana María Xet-Mull; Kristen L. Jurcic Smith; Dana M. Sisk; Daniel D. Hu; Rachel M. Cronin; Erika J. Hughes; W. Jared Brewer; Jörn Coers; Matthew M. Champion; Patricia A. Champion; Craig B. Lowe; Clare M. Smith; Sunhee Lee; Jason E. Stout; David M. Tobin
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)