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Autophagy and mTOR signaling during intervertebral disc aging and degeneration by Yurube, Takashi; Ito, Masaaki; Kakiuchi, Yuji; Kuroda, Ryosuke; Kakutani, Kenichiro is a Medicine article available to read on EtoBox.

What is Autophagy and mTOR signaling during intervertebral disc aging and degeneration about?

## Abstract Degenerative disc disease is a highly prevalent, global health problem that represents the primary cause of back pain and is associated with neurological disorders, including radiculopathy, myelopathy, and paralysis, resulting in worker disability and socioeconomic burdens. The intervertebral disc is the largest avascular organ in the body, and degeneration is suspected to be linked to nutritional deficiencies. Autophagy, the process through which cells self‐digest and recycle damaged components, is an important cell survival mechanism under stress conditions, especially nutrient deprivation. Autophagy is negatively controlled by the mammalian target of rapamycin (mTOR) signaling pathway. mTOR is a serine/threonine kinase that detects nutrient availability to trigger the activation of cell growth and protein synthesis pathways. Thus, resident disc cells may utilize autophagy and mTOR signaling to cope with harsh low‐nutrient conditions, such as low glucose, low oxygen, and low pH. We performed rabbit and human disc cell and tissue studies to elucidate the involvement and roles played by autophagy and mTOR signaling in the intervertebral disc. In vitro serum and nutrient

Who reads Autophagy and mTOR signaling during intervertebral disc aging and degeneration?

Author

Yurube, Takashi; Ito, Masaaki; Kakiuchi, Yuji; Kuroda, Ryosuke; Kakutani, Kenichiro

Publisher

Wiley (John Wiley & Sons); Wiley (ISSN 2572-1143)

Published

2020

Language

EN

Field

Medicine (Health Sciences)