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Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population by Yu Liu; Wenshan Gao; Claudia Koellmann; Sigrid Le Clerc; Anke Hüls; Bingjie Li; Qianqian Peng; Sijie Wu; Anan Ding; Yajun Yang; Li Jin; Jean Krutmann; Tamara Schikowski; Jean-François Zagury; Sijia Wang is a Medicine article available to read on EtoBox.

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## Background: The progression of human skin aging has a strong genetic basis. however, recent studies have mainly focused on caucasian populations and we have thus performed a genetic association study on skin aging signs in han chinese population. ## Objective: To investigate genetic risk factors in skin aging in han chinese female, we performed a genome-wide association study. ## Methods: We collected genotype data from 1534 han chinese female from taizhou cohort and evaluated 15 skin aging phenotypes by using the validated skin aging scinexaTM score. genetic associations were tested by linear and logistic regression analyses and adjusted for potential confounders. ## Results: Six genomic regions significantly associated with a risk for skin aging were revealed : 6q24.2 (rs3804540, p=4.6×10, additive model) with size of pigmented spots on forehead, 10q26.13 (rs4962295, p=1.9 ×10, additive model) with wrinkles under eyes, 15q21.1 (rs28392847, p=1.6×10, additive model) with crow's feet, 2p25.1 (rs191497052, p=5.5×10, dominant model) with telangiectasia, 13q34 (rs3825460, p=3.7×10, dominant model) with size of pigmented spots on cheeks and 16p13.11(rs76053540, p=5.0×10, dominant mo

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Author

Yu Liu; Wenshan Gao; Claudia Koellmann; Sigrid Le Clerc; Anke Hüls; Bingjie Li; Qianqian Peng; Sijie Wu; Anan Ding; Yajun Yang; Li Jin; Jean Krutmann; Tamara Schikowski; Jean-François Zagury; Sijia Wang

Published

2019

Language

EN

Field

Medicine (Health Sciences)