Can I read Preoperative Dose-Escalated Intensity-Modulated Radiotherapy (IMRT) and Intraoperative Radiation Therapy (IORT) in Patients with Retroperitoneal Soft-Tissue Sarcoma: Final Results of a Clinical Phase I/II Trial on EtoBox?

Preoperative Dose-Escalated Intensity-Modulated Radiotherapy (IMRT) and Intraoperative Radiation Therapy (IORT) in Patients with Retroperitoneal Soft-Tissue Sarcoma: Final Results of a Clinical Phase I/II Trial by Katharina Seidensaal; Matthias Dostal; Andreas Kudak; Cornelia Jaekel; Eva Meixner; Jakob Liermann; Fabian Weykamp; Philipp Hoegen; Gunhild Mechtersheimer; Franziska Willis; Martin Schneider; Jürgen Debus is a Medicine article available to read on EtoBox.

What is Preoperative Dose-Escalated Intensity-Modulated Radiotherapy (IMRT) and Intraoperative Radiation Therapy (IORT) in Patients with Retroperitoneal Soft-Tissue Sarcoma: Final Results of a Clinical Phase I/II Trial about?

## Simple Summary Retroperitoneal sarcomas represent a very rare entity. The most common pattern of recurrence and cause of death is local recurrence, and the rates of locoregional recurrences are high even at high-volume centers. In contrast to soft-tissue sarcomas of the extremities, the role of radiotherapy in retroperitoneal sarcoma is not fully established. The aim of the study was to report the results of a prospective single-center trial for preoperative dose-escalated intensity-modulated radiotherapy with an intraoperative boost in patients with retroperitoneal sarcoma after all surviving patients had achieved a follow-up of at least 60 months. The primary endpoint of a 5-year local control of 70% was not met; the local control of the cohort was 59.6%. In those patients who received a dose > 50 Gy and the intraoperative boost, the local control was promising at 64.8%. ## Abstract Background: To report the final results of a prospective, one-armed, single-center phase I/II trial (NCT01566123). Methods: Between 2007 and 2017, 37 patients with primary or recurrent (N = 6) retroperitoneal sarcomas were enrolled. Treatment included preoperative IMRT of 45–50 Gy with a simultaneo

Who reads Preoperative Dose-Escalated Intensity-Modulated Radiotherapy (IMRT) and Intraoperative Radiation Therapy (IORT) in Patients with Retroperitoneal Soft-Tissue Sarcoma: Final Results of a Clinical Phase I/II Trial?

Author

Katharina Seidensaal; Matthias Dostal; Andreas Kudak; Cornelia Jaekel; Eva Meixner; Jakob Liermann; Fabian Weykamp; Philipp Hoegen; Gunhild Mechtersheimer; Franziska Willis; Martin Schneider; Jürgen Debus

Publisher

MDPI AG

Published

2023

Language

EN

Field

Medicine (Health Sciences)