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Can I read Quality of Life During Neoadjuvant Treatment and After Surgery for Resectable Esophageal Carcinoma on EtoBox?
Quality of Life During Neoadjuvant Treatment and After Surgery for Resectable Esophageal Carcinoma by Esther van Meerten; Ate van der Gaast; Caspar W.N. Looman; Hugo W.G. Tilanus; Karin Muller; Marie-Louise Essink-Bot is a Medicine article available to read on EtoBox.
What is Quality of Life During Neoadjuvant Treatment and After Surgery for Resectable Esophageal Carcinoma about?
## Purpose: Because of the trade-off between the potentially negative quality-of-life (qol) effects and uncertain favorable survival effect of neoadjuvant chemoradiotherapy (crt) in patients with resectable esophageal cancer, we assessed heath-related qol (hrqol) for up to 1 year postoperatively in these patients treated with preoperative crt with a non-platinum-based outpatient regimen followed by esophagectomy. ## Methods and materials: Patients undergoing neoadjuvant paclitaxel and carboplatin therapy concurrent with radiotherapy followed by surgery completed standardized hrqol questionnaires before and after crt and at regular times up to 1 year postoperatively. we analyzed differences in generic qol core questionnaire [qlq-c30] and condition-specific (esophageal site-specific [oes-18]) hrqol scores over time by using a linear mixed-effects model. ## Results: Mean scores of most hrqol scales deteriorated significantly during neoadjuvant crt. the largest deterioration was observed for physical and role-functioning scales. all except two symptom scores worsened significantly. postoperatively, most mean hrqol scores improved until recovery to baseline level. speed of improvement v
Who reads Quality of Life During Neoadjuvant Treatment and After Surgery for Resectable Esophageal Carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Esther van Meerten; Ate van der Gaast; Caspar W.N. Looman; Hugo W.G. Tilanus; Karin Muller; Marie-Louise Essink-Bot
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)