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O11.4. Interactome Overlap Between Schizophrenia And Cognition by Elise Koch; Brin Rosenthale; Anders Lundquist; Chi-Hua Chen; Karolina Kauppi is a Medicine article available to read on EtoBox.

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## Abstract ## Background Cognitive impairments constitute a core feature of schizophrenia, and a genetic overlap between schizophrenia and cognitive functioning in healthy individuals has been identified. However, due to the high polygenicity and complex genetic architecture of both traits, overlapping biological pathways have not yet been identified between schizophrenia and normal cognitive ability. Network medicine offers a framework to study biologically meaningful gene networks through protein-protein interactions among risk genes. Here, established network-based methods were used to further reveal the biological relatedness of schizophrenia and cognition. ## Methods The protein interactome was used to examine the genetic link between schizophrenia risk genes and genes associated with cognitive performance in healthy individuals. First, we used a method called network separation to examine if there is an overlap between schizophrenia and cognition in the interactome network space. Then, we used network propagation analyses to identify schizophrenia risk genes that are close to cognition-associated genes in the interactome network space. Gene ontology and pathway enrichment an

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Author

Elise Koch; Brin Rosenthale; Anders Lundquist; Chi-Hua Chen; Karolina Kauppi

Publisher

Oxford University Press (OUP)

Published

2020

Language

EN

Field

Medicine (Health Sciences)