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Morphogenesis of Doublefoot (Dbf), a mouse mutant with polydactyly and craniofacial defects by CHRISTOPHER HAYES; MARY F. LYON; GILLIAN M. MORRISS-KAY is a Earth and Planetary Sciences article available to read on EtoBox.

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We report the morphogenesis of a new mouse mutant, Doublefoot (Dbf). The major phenotypic features involve the limb and craniofacial regions. There is polydactyly of all 4 limbs, with typically 6-8 digits per limb. All of the digits are triphalangeal; some show bifurcations and some are not attached to the carpus/tarsus. The carpus and tarsus are broader than normal, and their elements are partially fused. There are also tibial defects. Mutant embryos show a diencephalic bulge on d 10.0, with older animals exhibiting broadened and bulbous skulls sometimes with an additional midline skeletal element, shortened snouts and bulging eyes. Homozygotes, which do not survive beyond d 15, show midline facial clefting. In this study of the embryonic and fetal development of Dbf animals, we focus on the morphogenesis of the limbs and head, and discuss the possible molecular developmental mechanisms.

Who reads Morphogenesis of Doublefoot (Dbf), a mouse mutant with polydactyly and craniofacial defects?

Author

CHRISTOPHER HAYES; MARY F. LYON; GILLIAN M. MORRISS-KAY

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0021-8782)

Published

1998

Language

EN

Field

Earth and Planetary Sciences (Physical Sciences)