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Pre‐ and Postmortem Diffusion Coefficients in Rat Neural and Muscle Tissues by J. R. Macfall; J. H. Maki; G. A. Johnson; L. W. Hedlund; G. P. Cofer is a Medicine article available to read on EtoBox.

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## Abstract Pulsed gradient diffusion‐weighted spin‐echo images (7 to 11 gradient strengths) were obtained in a coronal slice through the midbrain for five normal adult white rats before and after sacrifice in a 2‐T CSI system with air temperature control. The pulse sequence was cardiac gated and respiratory synchronized in order to minimize motion artifacts (Tr > 2 s, Te ‐ 30 ms). Diffusion coefficients reflecting several tissue compartments (__D__^\*^) in brain and muscle were calculated and referenced to simultaneously imaged tubes of water. In the living animals, brain cortical matter had a value of __D__^\*^ = (0.82 ± 0.02) × 10^3^ mm^2^/s, deeper brain regions had a value of __D__^\*^ = (0.73 ± 0.02) × 10^‐3^ mm^2^/s, and the muscle had a value of __D__^\*^ = (1.4 ± 0.1) × 10^3^ mm^2^/s. Postmortem the values in brain dropped by approximately 30%, while remaining constant in muscle. Signal intensity in the spin‐echo images for muscle tissue rose by 50% over a 1‐ to 2‐h interval after sacrifice while that of brain tissue remained relatively stable. © 1991 Academic Press, Inc.

Who reads Pre‐ and Postmortem Diffusion Coefficients in Rat Neural and Muscle Tissues?

Author

J. R. Macfall; J. H. Maki; G. A. Johnson; L. W. Hedlund; G. P. Cofer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

1991

Language

EN

Field

Medicine (Health Sciences)