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Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates by Jeremiah J Davie; Josh Earl; Stefan PW de Vries; Azad Ahmed; Fen Z Hu; Hester J Bootsma; Kim Stol; Peter WM Hermans; Robert M Wadowsky; Garth D Ehrlich; John P Hays; Anthony A Campagnari is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates about?
## Background __M. catarrhalis__ is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM) and exacerbations of chronic obstructive pulmonary disease (COPD). With direct and indirect costs for treating these conditions annually exceeding $33 billion in the United States alone, and nearly ubiquitous resistance to beta-lactam antibiotics among __M. catarrhalis__ clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed. ## Results The genomic sequences of ten geographically and phenotypically diverse clinical isolates of __M. catarrhalis__ were determined and analyzed together with two publicly available genomes. These twelve genomes were subjected to detailed comparative and predictive analyses aimed at characterizing the supragenome and understanding the metabolic and pathogenic potential of this species. A total of 2383 gene clusters were identified, of which 1755 are core with the remaining 628 clusters unevenly distributed among the twelve isolates. These findings are consistent with the distributed genome hypothesis (DGH), which posits that the species genome possesses
Who reads Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jeremiah J Davie; Josh Earl; Stefan PW de Vries; Azad Ahmed; Fen Z Hu; Hester J Bootsma; Kim Stol; Peter WM Hermans; Robert M Wadowsky; Garth D Ehrlich; John P Hays; Anthony A Campagnari
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2164)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)