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Hyperfractionated accelerated radiation therapy for nonsmall cell lung cancer: Clinical phase III trial by Xiao-Long Fu; Guo-Liang Jiang; Li-Juan Wang; Hao Qian; Sen Fu; Ming Yie; Feng-Ming Kong; Sen Zhao; Shao-Qin He; Tai-Fu Liu is a Medicine article available to read on EtoBox.

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## Purpose: In an attempt to improve local control and survival of nonsmall cell lung cancer (nsclc), hyperfractionated accelerated radiation therapy (hart) was carried out as a clinical phase i/ii trial. ## Methods and materials: Hart was delivered by 1.1 gy/fraction, three fractions per day with intervals of 4 h and five treatment days per week. the clinical tumors were irradiated to 74.3 gy (72.6-75.9)/66-69 fx, 33 days (29-40) (not corrected for lung density), and the subclinical lesions, to 50.0 gy (48.4-50.6)/44-46 fx, 33 days (29-40). sixty-nine patients with nsclc were enrolled in this study. nine patients were withdrawn from the study during hart due to different reasons. sixty patients formed the study for outcome analyses. they were 57 males and 3 females with median age of 61 years (21-77). there were 41 cases of squamous cell carcinoma, 15 cases of adenocarcinoma, and 4 cases of large cell carcinoma. overall, favorable patients (kps > or = 70, weight loss < 5% and stages i, ii, iiia) accounted for 73% (44 of 60) of all patients. forty-four patients (73%) received adjuvant chemotherapy (ddp + vp16) with median cycles of 1.8 before and/or after hart. in order to compare

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Author

Xiao-Long Fu; Guo-Liang Jiang; Li-Juan Wang; Hao Qian; Sen Fu; Ming Yie; Feng-Ming Kong; Sen Zhao; Shao-Qin He; Tai-Fu Liu

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1997

Language

EN

Field

Medicine (Health Sciences)