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Long-term use of metformin and Alzheimer’s disease: beneficial or detrimental effects by Hayder M. Al-kuraishy; Ali I. Al-Gareeb; Hebatallah M. Saad; Gaber El-Saber Batiha is a Medicine article available to read on EtoBox.
What is Long-term use of metformin and Alzheimer’s disease: beneficial or detrimental effects about?
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by extracellular deposition of amyloid beta (Aβ) leading to cognitive decline. Evidence from epidemiological studies has shown the association between type 2 diabetes mellitus (T2DM) and the development of AD. T2DM and peripheral insulin resistance (IR) augment the risk of AD with the development of brain IR with inhibition of neuronal insulin receptors. These changes impair clearance of Aβ, increase secretion of Aβ 1-42 , reduce brain glucose metabolism, and abnormal deposition of Aβ plaques. Insulin-sensitizing drug metformin inhibits aggregation of Aβ by increasing the activity of the insulin-degrading enzyme (IDE) and neprilysin (NEP) levels. Additionally, different studies raised conflicting evidence concerning long-term metformin therapy in T2DM patients, as it may increase the risk of AD or it may prevent the progression of AD. Therefore, the objective of this review was to clarify the beneficial and detrimental effects of long-term metformin therapy in T2DM patients and risk of AD. Evidence from clinical trial studies revealed the little effect of metformin on AD. Various animal studies show
Who reads Long-term use of metformin and Alzheimer’s disease: beneficial or detrimental effects?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hayder M. Al-kuraishy; Ali I. Al-Gareeb; Hebatallah M. Saad; Gaber El-Saber Batiha
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)