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Can I read Osteopontin Controls Endothelial Cell Migration in Vitro and in Excised Human Valvular Tissue from Patients with Calcific Aortic Stenosis and Controls on EtoBox?
Osteopontin Controls Endothelial Cell Migration in Vitro and in Excised Human Valvular Tissue from Patients with Calcific Aortic Stenosis and Controls by Paolo Poggio; Juan B. Grau; Benjamin C. Field; Rachana Sainger; William F. Seefried; Flavio Rizzolio; Giovanni Ferrari is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Osteopontin Controls Endothelial Cell Migration in Vitro and in Excised Human Valvular Tissue from Patients with Calcific Aortic Stenosis and Controls about?
## Abstract Calcific aortic stenosis (CAS) is a pathological condition of the aortic valve characterized by dystrophic calcification of the valve leaflets. Despite the high prevalence and mortality associated with CAS, little is known about its pathogenetic mechanisms. Characterized by progressive dystrophic calcification of the valve leaflets, the early stages of aortic valve degeneration are similar to the active inflammatory process of atherosclerosis including endothelial disruption, inflammatory cell infiltration, lipid deposition, neo‐vascularization and calcification. In the vascular system, the endothelium is an important regulator of physiological and pathological conditions; however, the contribution of endothelial dysfunction to valvular degeneration at the cellular and molecular level has received little attention. Endothelial cell (EC) activation and neo‐vascularization of the cusps characterizes all stages of aortic valvular degeneration from aortic sclerosis to aortic stenosis. Here we reported the role of osteopontin (OPN) in the regulation of EC activation in vitro and in excised tissue from CAS patients and controls. OPN is an important pro‐angiogenic factor in se
Who reads Osteopontin Controls Endothelial Cell Migration in Vitro and in Excised Human Valvular Tissue from Patients with Calcific Aortic Stenosis and Controls?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Paolo Poggio; Juan B. Grau; Benjamin C. Field; Rachana Sainger; William F. Seefried; Flavio Rizzolio; Giovanni Ferrari
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)