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Synthesis of Centrolobine via IMOMA by sottorff is a document available to read on EtoBox.
This document discusses research on an enzyme called AmbDH3 that catalyzes an intramolecular oxa-Michael addition reaction to form chiral saturated oxygen heterocycles. The enzyme showed stability, substrate tolerance, and stereoselectivity in in vitro experiments. The researchers optimized reaction conditions to enable gram-scale conversions yielding preparative amounts of chiral tetrahydropyrans. They also demonstrated the synthetic utility of AmbDH3 by applying it in a key step of a chemoenzymatic total
- Author
- sottorff
- Language
- EN