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Inhibitory effect of glycolic acid on ultraviolet-induced skin tumorigenesis in SKH-1 hairless mice and its mechanism of action by Jin Tae Hong; Eun Joung Kim; Kwang Soo Ahn; Kyoung Mi Jung; Yeo Pyo Yun; Yong Keun Park; Sun Hee Lee is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract Glycolic acid, an alpha‐hydroxy acid derived from fruit and milk sugars, has been used commonly as a cosmetic ingredient since it was discovered to have photoprotective and anti‐inflammatory effects and antioxidant effects on ultraviolet (UV)B–irradiated skin. Little is known, however, about the functional role of glycolic acid on UV‐induced skin tumorigenesis. In the present study, we examined the effect of glycolic acid on UV (UVA + UVB)–induced skin tumorigenesis and assessed several significant contributing factors in SKH‐1 hairless mice. Inbred hairless female mice (15 animals/group) were irradiated for 5 d/wk at a total dose of 74.85 J/cm^2^ UVA and 2.44 J/cm^2^ UVB for 22 wk. Glycolic acid was applied topically twice a week at a dose of 8 mg/cm^2^ immediately after UV irradiation. Glycolic acid reduced UV‐induced skin tumor development. The protective effect of glycolic acid was a 20% reduction of skin tumor incidence, a 55% reduction of tumor multiplicity (average number of tumors/mouse), and a 47% decrease in the number of large tumors (larger than 2 mm). Glycolic acid also delayed the first appearance of tumor formation by about 3 wk. The inhibitory effect of
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It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jin Tae Hong; Eun Joung Kim; Kwang Soo Ahn; Kyoung Mi Jung; Yeo Pyo Yun; Yong Keun Park; Sun Hee Lee
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)