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Can I read Hexavalent Chromium Causes Apoptosis and Autophagy by Inducing Mitochondrial Dysfunction and Oxidative Stress in Broiler Cardiomyocytes on EtoBox?
Hexavalent Chromium Causes Apoptosis and Autophagy by Inducing Mitochondrial Dysfunction and Oxidative Stress in Broiler Cardiomyocytes by Hao Li; Jingjing Shi; Haihang Gao; Xiaoqi Yang; Yang Fu; Yuxuan Peng; Ying Xia; Donghai Zhou is a Environmental Science article available to read on EtoBox.
What is Hexavalent Chromium Causes Apoptosis and Autophagy by Inducing Mitochondrial Dysfunction and Oxidative Stress in Broiler Cardiomyocytes about?
Hexavalent chromium (Cr(VI)) is a common environmental pollutant, which has a strong toxic effect on humans and animals. However, the cardiac toxicity of Cr(VI) in broilers remains to be explored. The development of heart disease is often linked to mitochondrial dysfunction especially exposure to toxic substances. In order to investigate the role of mitochondrial dysfunction in apoptosis and autophagy of broiler cardiomyocytes induced by hexavalent chromium, broiler cardiomyocytes were cultured in potassium dichromate of 0 mM, 16 mM, and 32 mM medium for 24 h. The results showed that, compared with the control group, reactive oxygen species (ROS) and apoptosis rate in the Cr(VI) treatment group increased in a dosedependent manner, the mRNA levels of apoptosis-related genes Bax and p53 were significantly increased, and the mRNA level of Bcl-2 was significantly decreased. Compared with the control group, the mRNA level of autophagy-related genes (LC3-I, LC3-II, and Beclin1) in the Cr(VI) treatment group was significantly increased, the mRNA level of mTOR was significantly decreased, and the protein level of p62/SQSTM1 was significantly decreased. The protein level of Beclin1 and the
Who reads Hexavalent Chromium Causes Apoptosis and Autophagy by Inducing Mitochondrial Dysfunction and Oxidative Stress in Broiler Cardiomyocytes?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Hao Li; Jingjing Shi; Haihang Gao; Xiaoqi Yang; Yang Fu; Yuxuan Peng; Ying Xia; Donghai Zhou
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Environmental Science (Physical Sciences)