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18FDG PET/CT Scan Reveals Hypoactive Orbitofrontal Cortex in Anosmia of COVID-19 by Karimi-Galougahi, Mahboobeh; Yousefi-Koma, Abbas; Bakhshayeshkaram, Mehrdad; Raad, Nasim; Haseli, Sara is a Medicine article available to read on EtoBox.

What is 18FDG PET/CT Scan Reveals Hypoactive Orbitofrontal Cortex in Anosmia of COVID-19 about?

## Dear Editor, During the current nascent pandemic, anosmia has been increasingly reported among patients with coronavirus disease-2019 (COVID-19) (1). While postviral olfactory loss secondary to nasal congestion or conductive pathway alteration is a known sequela of sinonasal viral infections (2), anosmia of COVID-19 is less commonly associated with rhinorrhea or nasal congestion (3). This may indicate sensory neural loss as the underlying cause of the olfactory dysfunction rather than the conductive mechanism in most cases of postviral olfactory loss. We have recently reported normal morphology of the olfactory bulb on magnetic resonance imaging in anosmia of COVID-19 (4). Whether there is decreased neural activity in olfactory pathways despite normal morphology is unknown. We sought to assess the neural metabolic activity in anosmia of COVID-19 by 18fluoro-2-deoxy-d-glucose (18FDG) positron emission tomographyÀcomputed tomography (PET-CT). We included a 27-year-old healthy, right-handed woman, diagnosed with COVID-19 by polymerase chain reaction assay. The patient had persistent isolated anosmia for 6 weeks. She had no history of alcohol intake or tobacco smoking and no backgro

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Author

Karimi-Galougahi, Mahboobeh; Yousefi-Koma, Abbas; Bakhshayeshkaram, Mehrdad; Raad, Nasim; Haseli, Sara

Publisher

Elsevier Science; Elsevier ; Elsevier USA; Elsevier BV (ISSN 1076-6332)

Published

2020

Language

EN

Field

Medicine (Health Sciences)