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Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species by SiuKuin Wong; YauYan Lim; NoorRain Abdullah; FarizaJuliana Nordin is a Medicine article available to read on EtoBox.

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## Background: The anticancer properties of Apocynaceae species are well known in barks and roots but less so in leaves. ## Materials and Methods: In this study, leaf extracts of 10 Apocynaceae species were assessed for antiproliferative (APF) activities using the sulforhodamine B assay. Their extracts were also analyzed for total alkaloid content (TAC), total phenolic content (TPC), and radical scavenging activity (RSA) using the Dragendorff precipitation, Folin–Ciocalteu, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays, respectively. ## Results: Leaf extracts of __Alstonia angustiloba, Calotropis gigantea, Catharanthus roseus, Nerium oleander, Plumeria obtusa__, and __Vallaris glabra__ displayed positive APF activities. Extracts of __Allamanda cathartica, Cerbera odollam, Dyera costulata__, and __Kopsia fruticosa__ did not show any APF activity. Dichloromethane (DCM) extract of __C. gigantea__, and DCM and DCM:MeOH extracts of __V. glabra__ showed strong APF activities against all six human cancer cell lines. Against breast cancer cells of MCF-7 and MDA-MB-231, DCM extracts of __C. gigantea__ and __N. oleander__ were stronger than or comparable to standard drugs of xanthorrhizol,

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Author

SiuKuin Wong; YauYan Lim; NoorRain Abdullah; FarizaJuliana Nordin

Publisher

EManuscript Technologies

Published

2011

Language

EN

Field

Medicine (Life Sciences)