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Effect of melatonin administration on qPer2, qPer3, and qClock gene expression in the suprachiasmatic nucleus of Japanese quail by Shinobu Yasuo; Takashi Yoshimura; Paul A. Bartell; Masayuki Iigo; Eri Makino; Naritoshi Okabayashi; Shizufumi Ebihara is a Neuroscience article available to read on EtoBox.

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## Abstract Temporal changes of mRNA expression of three clock genes, __qPer2__, __qPer3__ and __qClock,__ were studied in the suprachiasmatic nucleus (SCN) of Japanese quail under different light conditions, as well as under the condition of continuous melatonin. In addition, the expression of melatonin receptor genes, __Mel__~__1a__~ and __Mel__~__1c__~, in the SCN were also examined. The expression of __qPer2__ mRNA showed robust oscillation during both light and dark (LD) 12:12 cycles and under constant dark conditions (DD), but did not exhibit circadian rhythmicity in constant light conditions (LL), instead being expressed at a consistently high level. Expression of __qPer3__ also showed robust oscillation under both LD and DD conditions. Unlike __qPer2__ however, __qPer3__ mRNA expression remained rhythmic under LL conditions. Contrary to the findings on the other clock genes, no remarkable rhythmicity was detectable in either light condition. Both __Mel__~__1a__~ and __Mel__~__1c__~ mRNAs were detected in the SCN, however, __Mel__~__1a__~ mRNA levels were higher than __Mel__~__1c__~ and showed daily rhythmicity. Although implantation of melatonin tubes caused constant high l

Who reads Effect of melatonin administration on qPer2, qPer3, and qClock gene expression in the suprachiasmatic nucleus of Japanese quail?

Author

Shinobu Yasuo; Takashi Yoshimura; Paul A. Bartell; Masayuki Iigo; Eri Makino; Naritoshi Okabayashi; Shizufumi Ebihara

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)