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Rituximab and cyclosporine therapy for accelerated phase Chediak–Higashi syndrome by Chikara Ogimi; Risa Tanaka; Takashi Arai; Akira Kikuchi; Ryoji Hanada; Tsutomu Oh-ishi is a Medicine article available to read on EtoBox.
What is Rituximab and cyclosporine therapy for accelerated phase Chediak–Higashi syndrome about?
## Abstract A 19‐month‐old male with Chediak–Higashi syndrome developed Epstein–Barr virus (EBV)‐associated accelerated phase. Real‐time polymerase chain reaction showed high EBV–DNA levels in plasma and peripheral blood mononuclear cells. His condition was refractory to conventional treatments for hemophagocytic lymphohistiocytosis, including corticosteroids, cyclosporine, and etoposide. In situ hybridization revealed higher proportion of EBER‐1‐positive cells in CD19+ cell fraction than in CD8+ cell fraction. Complete remission was achieved by combination therapy with rituximab and cyclosporine; subsequent bone marrow transplantation was successful. Combination therapy with rituximab and cyclosporine could be effective in patients with EBV‐infected T and B cells. Pediatr Blood Cancer 2011; 57: 677–680. © 2011 Wiley‐Liss, Inc.
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chikara Ogimi; Risa Tanaka; Takashi Arai; Akira Kikuchi; Ryoji Hanada; Tsutomu Oh-ishi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)