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Selectivity as Well as Sensitivity Loss Characterizes the Cortical Spatial Frequency Deficit in Amblyopia by Robert F. Hess; Xingfeng Li; Behzad Mansouri; Benjamin Thompson; Bruce C. Hansen is a Neuroscience article available to read on EtoBox.

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## Abstract The processing deficit in amblyopia is not restricted to just high spatial frequencies but also involves low‐medium spatial frequency processing, for suprathreshold stimuli with a broad orientational bandwidth. This is the case in all three forms of amblyopia; strabismic, anisometropic, and deprivation. Here we use both a random block design and a phase‐encoded design to ascertain (1) the extent to which fMRI activation is reduced at low‐mid spatial frequencies in different visual areas, (2) how accurately spatial frequency is mapped across the amblyopic cortex. We report a loss of function to suprathreshold low‐medium spatial frequency stimuli that involves more than just area V1, suggesting a diffuse loss in spatial frequency processing in a number of different cortical areas. An analysis of the fidelity of the spatial frequency cortical map reveals that many voxels lose their spatial frequency preference when driven by the amblyopic eye, suggesting a broader tuning for spatial frequency for neurons driven by the amblyopic eye within this low‐mid spatial frequency range. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.

Who reads Selectivity as Well as Sensitivity Loss Characterizes the Cortical Spatial Frequency Deficit in Amblyopia?

Author

Robert F. Hess; Xingfeng Li; Behzad Mansouri; Benjamin Thompson; Bruce C. Hansen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)