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Renal Bone Disease by Thomas Phillips; Cathy Pogson; Kristin Veighey; John Cunningham is a scholarly article available to read on EtoBox.

What is Renal Bone Disease about?

Sustained loss of kidney function leads to the evolution of progressive secondary hyperparathyroidism associated with a characteristic high-turnover form of metabolic bone disease. The drivers of hyperparathyroidism include the failure of renal bioactivation of vitamin D, phosphate retention and, in some cases, hypocalcaemia. As renal impairment becomes more severe, some patients, particularly under the influence of treatment, and particularly if they have diabetes, evolve in a different direction; here, low-turnover adynamic bone disease develops, associated with relative suppression of the parathyroid glands. Uraemic patients also develop an internal milieu that favours soft tissue calcification involving the peri-articular tissue, skin and vasculature. Arterial calcification is closely associated with arterial stiffening, left ventricular disease and increased cardiovascular morbidity and mortality. Current therapies aim to minimize disturbances of skeletal integrity by maintaining calcium, phosphate, vitamin D and parathyroid hormone concentrations within defined target ranges. It is hoped, but not yet established, that these measures will also result in a reduction of cardiova

Author

Thomas Phillips; Cathy Pogson; Kristin Veighey; John Cunningham

Publisher

Elsevier BV

Published

2023

Language

EN