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Efficacy and Tolerability of Perampanel as a First Add-on Therapy with Different Anti-seizure Drugs by Estevo Santamarina; Vicente Bertol; Vanesa Garayoa; María José García-Gomara; Iñigo Garamendi-Ruiz; Pau Giner; Inés Aranzábal; Anna Piera; Carolina Arcos; Patricia Esteve; Ainhoa Marinas; Alejandro García-Escrivá; Alejandro Viloria-Alebesque; Fernando Ayuga Loro; Alejandro Ponz de Tienda; José Antonio Olivan; Macarena Bonet; Pablo Dávila-González; Rafael Sivera; Albert Molins; Gemma Sansa; José Carlos Roche; Ana Belén Martínez; Sandra Monteagudo; Teresa Casadevall is a Medicine article available to read on EtoBox.

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## Purpose: To investigate the efficacy and tolerability of perampanel (per) when administered as a first add-on therapy to patients with focal epilepsy or idiopathic generalized epilepsy (ige) taking one other antiseizure drug (asd). ## Methods: This multicentre, retrospective, one-year observational study collected data from patients (≥12 years) who initiated treatment with per as first add-on therapy. patients had to be experiencing inadequate seizure control on asd monotherapy and tried ≤3 asd monotherapies before initiating per. multivariate logistic regression analyses were performed, adjusted for the number and type of previous seizures, duration and aetiology of epilepsy. ## Results: Of the 149 patients included in the study (mean age 41 years; 54.4 % male), 118 (79.2 %) were still receiving per as first add-on treatment after 12 months. mean per dose was 6.2 mg/day. at 12 months, 45.6 % were seizure-free and 84.6 % responders. a significant difference in seizure freedom rate was found between patients with ige and patients with focal epilepsy, but not in responders. reduced seizure control was observed when per was administered with strong enzyme-inducing asds; conversely,

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Author

Estevo Santamarina; Vicente Bertol; Vanesa Garayoa; María José García-Gomara; Iñigo Garamendi-Ruiz; Pau Giner; Inés Aranzábal; Anna Piera; Carolina Arcos; Patricia Esteve; Ainhoa Marinas; Alejandro García-Escrivá; Alejandro Viloria-Alebesque; Fernando Ayuga Loro; Alejandro Ponz de Tienda; José Antonio Olivan; Macarena Bonet; Pablo Dávila-González; Rafael Sivera; Albert Molins; Gemma Sansa; José Carlos Roche; Ana Belén Martínez; Sandra Monteagudo; Teresa Casadevall

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)