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Efficacy of mefloquine and mefloquine–artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon region of Bolivia by Juan Carlos Avila; Rodolfo Villaroel; Wilmer Marquiño; Jorge Zegarra; René Mollinedo; Trenton K. Ruebush is a Medicine article available to read on EtoBox.
What is Efficacy of mefloquine and mefloquine–artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon region of Bolivia about?
## Summary We assessed the efficacy of mefloquine monotherapy and mefloquine–artesunate (MQ–AS) combination therapy for the treatment of __Plasmodium falciparum__ malaria at four sites in the Bolivian Amazon region. Patients with uncomplicated __P. falciparum__ infections between 5 and 60 years of age were randomly assigned to be treated with either MQ (15 mg/kg in a single oral dose) or MQ (15 mg/kg) plus AS (4 mg/kg daily for 3 days). A total of 143 patients were enrolled and followed for 28 days. None of the 73 patients who received MQ alone or the 70 patients who received MQ–AS combination therapy had recurrences of parasitaemia during the 28‐day follow‐up period. Asexual parasite densities fell significantly more rapidly and the proportion of patients with gametocytes was significantly lower on days 7–28 in patients treated with MQ–AS than in those treated with MQ alone. All patients tolerated the medications well. After this study, the Bolivian Ministry of Public Health changed its treatment policy for uncomplicated __P. falciparum__ malaria in the Amazon region to combination therapy with MQ–AS to slow or prevent the development of resistance.
Who reads Efficacy of mefloquine and mefloquine–artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon region of Bolivia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Juan Carlos Avila; Rodolfo Villaroel; Wilmer Marquiño; Jorge Zegarra; René Mollinedo; Trenton K. Ruebush
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; ScienceOpen (ISSN 1360-2276)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)