Can I read Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth on EtoBox?
Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth by M. Staresinic; B. Sebecic; L. Patrlj; S. Jadrijevic; S. Suknaic; D. Perovic; G. Aralica; N. Zarkovic; S. Borovic; M. Srdjak; K. Hajdarevic; M. Kopljar; L. Batelja; A. Boban‐Blagaic; I. Turcic; T. Anic; S. Seiwerth; P. Sikiric is a Medicine article available to read on EtoBox.
What is Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth about?
## Abstract In studies intended to improve healing of transected Achilles tendon, effective was a stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419). Currently in clinical trials for inflammatory bowel disease (PLD‐116, PL 14736, Pliva), it ameliorates internal and external wound healing. In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends. Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 μg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy. Achilles functional index (AFI) was assessed once time daily. Biomechanical, microscopical and macroscopical assessment was on day 1, 4, 7, 10 and 14. Controls generally have severely compromised healing. In comparison, pentadecapeptide BPC 157 fully improves recovery: (i) biomechanically, increased load of failure, load of failure per area and Young's modulus of elasticity; (ii) functionally, significantly higher AFI‐values; (iii) microscopically, more mononuclears and less granulocytes, superior formation of
Who reads Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- M. Staresinic; B. Sebecic; L. Patrlj; S. Jadrijevic; S. Suknaic; D. Perovic; G. Aralica; N. Zarkovic; S. Borovic; M. Srdjak; K. Hajdarevic; M. Kopljar; L. Batelja; A. Boban‐Blagaic; I. Turcic; T. Anic; S. Seiwerth; P. Sikiric
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)