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Structure Elucidation of a Novel Synthetic Thiono Analogue of Sildenafil Detected in an Alleged Herbal Aphrodisiac by B.J. Venhuis; G. Zomer; D. de Kaste is a scholarly article available to read on EtoBox.

What is Structure Elucidation of a Novel Synthetic Thiono Analogue of Sildenafil Detected in an Alleged Herbal Aphrodisiac about?

A new analogue of sildenafil was detected in a herbal aphrodisiac. The structure of the compound was established using LC-MS, UV and IR spectroscopy, MS-MS, and NMR. The compound, named thio-homosildenafil is a synthetic N-ethylpiperazine analogue of sildenafil in which also the CO moiety has been converted into a CS group. This is the first time a sildenafil analogue modified at the chromophore was identified as an adulterant of a herbal aphrodisiac. Preliminary pharmacological analysis confirmed the erectogenic potency of thio-homosildenafil.

Author

B.J. Venhuis; G. Zomer; D. de Kaste

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)

Published

2008

Language

EN