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1. The serotonin receptor 2A (5-HT2A) plays a key role in mental health conditions like depression and schizophrenia. Depending on its molecular features, a 5-HT2A agonist can activate different intracellular signaling pathways. 2. The project aimed to develop conformationally restricted phenethylamine agonists of 5-HT2A and evaluate how structural changes affect functional selectivity between signaling pathways. 3. A boronic acid sulfonyl hydrazone coupling reaction was found to synthesize the target c

Author

joebob

Language

EN