Can I read Computational flow analysis of the washout of an aortic valve by means of Eulerian transport equation on EtoBox?

Computational flow analysis of the washout of an aortic valve by means of Eulerian transport equation by Michael Stiehm; Finja Borowski; Sebastian Kaule; Robert Ott; Sylvia Pfensig; Stefan Siewert; Klaus-Peter Schmitz; Alper Ö Öner; Niels Grabow is a scholarly article available to read on EtoBox.

What is Computational flow analysis of the washout of an aortic valve by means of Eulerian transport equation about?

## Abstract Although the development of the transcatheter aortic valve (TAV) has saved many lives of inoperable patients and has a very good clinical outcome, concerns about valve thrombosis are increasing. Due to the potential risk of late clinically relevant events, the US Food and Drug Administration (FDA) suggests a careful systematic investigation of thrombosis and reduced leaflet motion related to hemodynamic changes induced by TAV implantation. Furthermore, recently published position papers of the ISO working group address numerical and experimental flow field assessment of TAV. In particular, pathologically high shear rates and a reduced washout of the sinuses may increase the risk of valve thrombosis and should therefore be investigated. By means of fluid-structure interaction (FSI) as a powerful in silico tool, the transient flow field in an aortic valve was analyzed. A linear elastic behavior was assumed for leaflet material properties (Young modulus: 10 MPa, Poisson ratio: 0.46 and leaflet material density: 1000 kg/m^3^) and blood was specified as a homogeneous, Newtonian and incompressible fluid (fluid density: 1060 kg/m^3^ and a dynamic viscosity: 0.0035 Pa s). In th

Author

Michael Stiehm; Finja Borowski; Sebastian Kaule; Robert Ott; Sylvia Pfensig; Stefan Siewert; Klaus-Peter Schmitz; Alper Ö Öner; Niels Grabow

Publisher

Walter de Gruyter GmbH

Published

2019

Language

EN