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Can I read Bergenin alleviates myocardial ischemia‐reperfusion injury via SIRT1 signaling on EtoBox?
Bergenin alleviates myocardial ischemia‐reperfusion injury via SIRT1 signaling by Yingying Liu; Yanzhen Tan; Guojie Cao; Lei Shi; Yujie Song; Wenju Shan; Miao Zhang; Panpan Li; Haitao Zhou; Bing Zhang; Yang Sun; Wei Yi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Bergenin alleviates myocardial ischemia‐reperfusion injury via SIRT1 signaling about?
Myocardial ischemia-reperfusion (MI/R) is a major risk factor for cardiovascular disease. At present, reducing oxidative stress and apoptosis is a crucial therapeutic strategy for ameliorating MI/R injury. However, there is a lack of drugs targeting oxidative stress and apoptosis for the clinical therapy of MI/R. Bergenin is a reportedly effective agent with antioxidative and antiapoptotic activity against acute injury. Nevertheless, the roles and potential mechanisms of bergenin against MI/R injury remain unknown. Here, we hypothesized that bergenin attenuated MI/R-induced apoptosis and reactive oxygen species (ROS) production via SIRT1. Mice were subjected to MI/R and treated with bergenin, after which the cardiac function, cardiomyocyte apoptosis, LDH release, and MDA content were evaluated. In vitro, myocardial injury model of H9c2 cells was induced by simulated ischemia/reperfusion (SI/R), apoptosis and oxidative stress was decreased after treated with bergenin. Bergenin significantly reduced myocardial apoptosis and ROS generation in vitro and improved cardiac function in vivo. Intriguingly, bergenin remarkably decreased apoptosis in cardiac tissue accompanied by SIRT1 upregu
Who reads Bergenin alleviates myocardial ischemia‐reperfusion injury via SIRT1 signaling?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yingying Liu; Yanzhen Tan; Guojie Cao; Lei Shi; Yujie Song; Wenju Shan; Miao Zhang; Panpan Li; Haitao Zhou; Bing Zhang; Yang Sun; Wei Yi
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)