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Models for estimation of the 10B concentration after BPA-fructose complex infusion in patients during epithermal neutron irradiation in BNCT by Päivi M. Ryynänen; Mika Kortesniemi; Jeffrey A. Coderre; Aidnag Z. Diaz; Pekka Hiismäki; Sauli E. Savolainen is a Medicine article available to read on EtoBox.
What is Models for estimation of the 10B concentration after BPA-fructose complex infusion in patients during epithermal neutron irradiation in BNCT about?
## Purpose: To create simple and reliable models for clinical practice for estimating the blood (10)b time-concentration curve after p-boronophenylalanine fructose complex (bpa-f) infusion in patients during neutron irradiation in boron neutron capture therapy (bnct). ## Methods and materials: Bpa-f (290 mg bpa/kg body weight) was infused i.v. during two hours to 10 glioblastoma multiforme patients. blood samples were collected during and after the infusion. compartmental models and bi-exponential function fit were constructed based on the (10)b blood time-concentration curve. the constructed models were tested with data from six additional patients who received various amounts of infused bpa-f and data from one patient who received a one-hour infusion of 170 mg bpa/kg body weight. ## Results: The resulting open two-compartment model and bi-exponential function estimate the clearance of (10)b after 290 mg bpa/kg body weight infusion from the blood with satisfactory accuracy during the first irradiation field (1 ppm, i.e., 7%). the accuracy of the two models in predicting the clearance of (10)b during the second irradiation field are for two-compartment model 1.0 ppm (8%) and 0.2 pp
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- Author
- Päivi M. Ryynänen; Mika Kortesniemi; Jeffrey A. Coderre; Aidnag Z. Diaz; Pekka Hiismäki; Sauli E. Savolainen
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)