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This study investigates the in silico antimalarial activity of compounds from Irvingia wombulu against the Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) enzyme in Plasmodium falciparum. The research identifies 44 phytoconstituents through gas chromatography/mass spectrometry and evaluates their binding energies, with alpha-tocopherol-beta-D-mannoside showing the best results. The findings suggest that these compounds have potential for development into new antimalarial drugs due to their favorable

Author

Lipsa Routray

Language

EN